POST TO A COLLEAGUE 07/31/2022
Agreed, NAD+ is much too large to enter the cell and has no specific cell receptor to enter the cell.
This data comes directly from the Leading NAD+ Molecular Biologist Researcher and NAD+ Scientist Experts, Yoshino & Shin.
They explain in a few publications that you need the precursors, NR/NMN which is taken in through the cell transporter to me converted to NAD+, rather than just giving NAD+ by itself...as its much to large IV and degraded if taken by mouth...
Dr. Sinclair's Harvard Longevity Lab has PUBMED-NCBI Peer Reviewed Global Publications which contain loads of NAD+ Black and White Results Data along with quite a bit of data on the NAD+ Sirtuins connection for DNA Repair...
SEE VIDEO BELOW: DR SINCLAIR HARVARD LONGEVITY
Many NAD+ Scientists are now saying, you can't just use NAD+ as a standalone to optimize the cell Mitochondria, rather adding the correct concentration of co- factor, co-enzymes and peptides as obligatory components...
Which, not surprisingly we are finding in black and white patient outcome results via Validated Surveys, QEEGs and Brain Imaging...
I too agreed Dr. Jin Xiong She, it should be less about the biostats and more about the black nd white patient outcome results.
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions Mounica Soma 1, Satya Kumar Lalam 2 Affiliations expand
PMID: 35441939
DOI: 10.1007/s11033-022-07459-1
Abstract Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD+) has recently gained a lot of attention. A systemic decline in NAD+ across many tissues is associated with all the hallmarks of aging. NAD+ can affect a variety of cellular processes, including metabolic pathways, DNA repair, and immune cell activity, both directly and indirectly. These cellular processes play a vital role in maintaining homeostasis, but as people get older, their tissue and cellular NAD+ levels decrease, and this drop in NAD+ levels has been connected to a number of age-related disorders. By restoring NAD+ levels,…
Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.Nadeeshani H, Li J, Ying T, Zhang B, Lu J.J Adv Res. 2021 Aug 11;37:267-278. doi: 10.1016/j.jare.2021.08.003. eCollection 2022 Mar.PMID: 35499054 Free PMC article. Review.
Systemic pyruvate administration markedly reduces neuronal death and cognitive impairment in a rat model of Alzheimer's disease.Wang X, Hu X, Yang Y, Takata T, Sakurai T.Exp Neurol. 2015 Sep;271:145-54. doi: 10.1016/j.expneurol.2015.06.008. Epub 2015 Jun 7.PMID: 26057947
Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats.Wang X, Hu X, Zhang L, Xu X, Sakurai T.Brain Res Bull. 2020 Jul;160:98-106. doi: 10.1016/j.brainresbull.2020.04.022. Epub 2020 May 5.PMID: 32380185
Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons.Chandrasekaran…
Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death - PubMed (nih.gov)
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions - PubMed (nih.gov)
Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns - PubMed (nih.gov)